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The mediation analysis determined that changes in AHI and SASHB significantly mediated reductions in hsCRP, HOMA-IR and triglycerides, but notably, there was no positive mediation of AHI and SASHB observed on SBP and DBP
Significant decreases were observed in BMI, C-reactive protein, homocysteine, ferritin, and plasma cortisol levels, alongside significant improvements in PASI and DLQI
Patients taking Mazdutide experienced an average weight loss of 7% to 9%, and the drug outperformed Trulicity in both weight loss and A1C reduction
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